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Eplerenone in Patients with Systolic Heart  @Sarah Gen– When prednisone withdrawal symptoms are severe, it’s a good idea to return to your last dose and taper down more. Orinal Article. Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms. Faiez Zannad, M. D. Ph. D. John J. V. McMurray, M. D. Henry Krum, M.