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Tips for reducing water retention and ankle swelling? Archive. ), but I don't know where to discuss about it, whenever I post in Healthy Living about health issues it gets moved :shrugs: So hey, I got on methadone in october, all is going well, it did its job at having me not want to shoot up dilaudid and eat oxycodone as food and not do anything out of my days. I know methadone can cause water retention, when in the waiting room at. Prednisone will just cause more water retention in the long run.
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