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What is the difference betweeen a Schedule I drug. Yahoo Answers Among the substances so classified by the Drug Enforcement Agency are coral hydrate, cordiazepoxide, meprobamate, and oxazepam. What is the difference betweeen a Schedule I drug and Schedule II or III? Reason I ask is one of my good friend's friend got busted for possession of some illicit drug. I don't know what it was but it was Schedule II, I believe he said.